Yutaka Kakizoe Selected Research

camostat

8/2021	A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats.
10/2016	A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity.
2/2016	Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.
1/2015	The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects.
7/2013	The antifibrotic effect of a serine protease inhibitor in the kidney.
1/2009	Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension.

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Yutaka Kakizoe Research Topics

Disease

7	Hypertension (High Blood Pressure) 11/2021 - 01/2009
7	Fibrosis (Cirrhosis) 08/2019 - 10/2012
4	Chronic Renal Insufficiency 11/2019 - 01/2015
3	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 11/2018
3	Proteinuria 08/2021 - 10/2012
3	Wounds and Injuries (Trauma) 08/2021 - 12/2014
3	Kidney Diseases (Kidney Disease) 08/2019 - 10/2016
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 08/2021 - 11/2019
2	Chronic Kidney Failure (Chronic Renal Failure) 02/2021 - 10/2012
2	Albuminuria 11/2020 - 01/2016
2	Acidosis 11/2019 - 01/2017
2	Neoplasms (Cancer) 12/2018 - 11/2018
2	Ureteral Obstruction 10/2016 - 07/2013
1	Reperfusion Injury 01/2022
1	Ischemia 01/2022
1	Rodent Diseases 08/2021
1	Anemia 02/2021
1	Disease Progression 11/2020
1	Sensorineural Hearing Loss 01/2020
1	Premature Aging 01/2020
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2020
1	Obesity 11/2019
1	Overweight 11/2019
1	Inflammation (Inflammations) 08/2019
1	Body Weight (Weight, Body) 11/2018
1	Infections 11/2018
1	Edema (Dropsy) 01/2018
1	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2018
1	Hypoaldosteronism (Hyporeninemic Hypoaldosteronism) 01/2018
1	Alkalosis 01/2018
1	Hypoalbuminemia 01/2018
1	Hypokalemia 01/2018
1	Polyneuropathies (Polyneuropathy) 04/2016
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2016
1	Insulin Resistance 03/2014
1	Type 2 Diabetes Mellitus (MODY) 11/2013
1	Dehydration (Water Stress) 01/2013

Drug/Important Bio-Agent (IBA)

7	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 08/2021 - 10/2012
7	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2012
6	camostatIBA 08/2021 - 01/2009
5	SaltsIBA 11/2021 - 01/2009
4	CreatinineIBA 01/2022 - 10/2012
3	Serine Proteases (Serine Protease)IBA 08/2021 - 03/2014
3	Messenger RNA (mRNA)IBA 01/2017 - 08/2009
2	nephrinIBA 11/2020 - 10/2012
2	Toll-Like Receptor 4IBA 01/2020 - 03/2014
2	Cisplatin (Platino)FDA LinkGeneric 12/2018 - 11/2018
2	Epithelial Sodium ChannelsIBA 01/2018 - 01/2012
2	Amiloride (Midamor)FDA LinkGeneric 01/2018 - 08/2009
2	AldosteroneIBA 10/2016 - 08/2009
2	Adenine FDA LinkGeneric 02/2016 - 01/2015
2	prostasinIBA 03/2014 - 01/2009
2	CollagenIBA 07/2013 - 10/2012
1	Valosin Containing ProteinIBA 01/2022
1	KUS121IBA 01/2022
1	Adenosine Triphosphate (ATP)IBA 01/2022
1	Lipocalin-2IBA 01/2022
1	continuous erythropoietin receptor activator FDA Link 02/2021
1	RNA (Ribonucleic Acid)IBA 11/2020
1	LigandsIBA 01/2020
1	AcidsIBA 11/2019
1	Sodium Chloride FDA LinkGeneric 11/2019
1	Ammonium CompoundsIBA 11/2019
1	edoxabanIBA 08/2019
1	Blood Coagulation Factors (Coagulation Factor)IBA 08/2019
1	SirtuinsIBA 12/2018
1	Drinking WaterIBA 11/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 11/2018
1	Tetracycline (Achromycin)FDA LinkGeneric 11/2018
1	Doxycycline (Periostat)FDA LinkGeneric 11/2018
1	Pharmaceutical PreparationsIBA 11/2018
1	Spironolactone (Aldactone)FDA LinkGeneric 01/2018
1	SteroidsIBA 01/2018
1	Triamterene (Dyrenium)FDA LinkGeneric 01/2018
1	Potassium Sparing DiureticsIBA 01/2018
1	benzyloxycarbonylleucyl-leucyl-leucine aldehydeIBA 01/2017
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2017
1	Proteasome InhibitorsIBA 01/2017
1	UbiquitinIBA 01/2017
1	Fibrinolysin FDA Link 10/2016
1	Prealbumin (Transthyretin)IBA 04/2016
1	Telmisartan (Micardis)FDA Link 02/2016
1	AntioxidantsIBA 01/2015
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2015
1	Streptozocin (Streptozotocin)FDA Link 12/2014
1	ThiazolidinedionesIBA 11/2013
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 11/2013
1	Connective Tissue Growth FactorIBA 07/2013
1	Plasminogen Activators (Plasminogen Activator)IBA 07/2013
1	Transforming Growth Factors (Transforming Growth Factor)IBA 07/2013
1	Hydroxyproline (4 Hydroxyproline)IBA 07/2013
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 07/2013
1	Prostaglandin-E SynthasesIBA 01/2013
1	Natriuretic AgentsIBA 01/2013
1	Prostaglandins EIBA 01/2013
1	Dinoprostone (PGE2)FDA Link 01/2013

Therapy/Procedure

3	Therapeutics 12/2018 - 01/2016
1	Peritoneal Dialysis 02/2021
1	Renal Dialysis (Hemodialysis) 01/2020
1	Gastrectomy 01/2018